Image Data Collection
Cognitive Baseline Stability
Because the cognitive and motor activity engaged in by a subject are associated with neuronal activation,
they can confound the imaging signal that is specifically related to the drug state. This is particularly the
case in functional imaging studies. Abiant uses a proprietary process combining a subject control task
with measurement of mood during radioisotope uptake, to ensure a consistent state from scan to scan.
Task performance, response time, and mood are automatically measured and used for quality control
and correlation to image data. Targeted cognitive tasks performed during radiotracer uptake can also be
used to optimize discrimination in certain brain regions. The degree to which these processes are
employed, and which tasks are used, depend upon the type of imaging study and the subject population.
Because the cognitive and motor activity engaged in by a subject are associated with neuronal activation,
they can confound the imaging signal that is specifically related to the drug state. This is particularly the
case in functional imaging studies. Abiant uses a proprietary process combining a subject control task
with measurement of mood during radioisotope uptake, to ensure a consistent state from scan to scan.
Task performance, response time, and mood are automatically measured and used for quality control
and correlation to image data. Targeted cognitive tasks performed during radiotracer uptake can also be
used to optimize discrimination in certain brain regions. The degree to which these processes are
employed, and which tasks are used, depend upon the type of imaging study and the subject population.
| Copyright 2006 - 2008 Abiant, Inc. |
Technology
Advanced BioImaging to Accelerate New Therapeutics
Site selection and qualification
The selection, validation, training, and monitoring of the PET site can also have a material impact upon
image data quality. Abiant's team has developed an international network of PET and clinical sites,
selected based upon factors including equipment, radiochemistry capabilities, staff expertise and
adherence to protocols, proximity to relevant subject populations, clinical resources, and capacity.
Abiant:
The selection, validation, training, and monitoring of the PET site can also have a material impact upon
image data quality. Abiant's team has developed an international network of PET and clinical sites,
selected based upon factors including equipment, radiochemistry capabilities, staff expertise and
adherence to protocols, proximity to relevant subject populations, clinical resources, and capacity.
Abiant:
- Evaluates each site; validates imaging equipment
- Provides Standard Operating Procedures with
- numerous quality controls that are important to
reliable data collection
- Trains staff at all sites
- Selects and manages clinical lab tests
- Coordinates and monitors site resources
- Processes all data centrally.
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